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Pharmacogenomics in cancer drug discovery and development: inhibitors of the Hsp90 molecular chaperone

✍ Scribed by Paul Workman

Book ID
114238115
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
87 KB
Volume
26
Category
Article
ISSN
0361-090X

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## Abstract Activation of the Hsp90 chaperone system is a characteristic of cancer cells. The regulation of chaperone activities involves their interaction with cochaperones; therefore we investigated the expression of Hsp70 and Hsp90 and their specific co-chaperones HOP and CHIP in cancer cell lin