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Targeting the Hsp90 Chaperone: Synthesis of Novel Resorcylic Acid Macrolactone Inhibitors of Hsp90

✍ Scribed by James E. H. Day; Swee Y. Sharp; Martin G. Rowlands; Wynne Aherne; Paul Workman; Christopher J. Moody


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
389 KB
Volume
16
Category
Article
ISSN
0947-6539

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The effects of GA, an ansamycin antibiotic in development as a lead anticancer drug, were studied in mouse BP-A31 fibroblasts and in human cancer-derived cell lines. GA and related molecules act by inhibiting the chaperone function of the Hsp90 protein through competition for ATP binding. The antipr