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Inhibition of Hsp90 with Resorcylic Acid Macrolactones: Synthesis and Binding Studies

✍ Scribed by Dr. James E. H. Day; Dr. Swee Y. Sharp; Dr. Martin G. Rowlands; Dr. Wynne Aherne; Dr. William Lewis; Dr. S. Mark Roe; Dr. Chrisostomos Prodromou; Prof. Dr. Laurence H. Pearl; Prof. Dr. Paul Workman; Prof. Dr. Christopher J. Moody


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
545 KB
Volume
16
Category
Article
ISSN
0947-6539

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The posttranslational deformylation of N-formyl-Met-polypeptides by the metalloenzyme, peptide deformylase, is essential for bacterial growth. Methionine hydroxamic acid derivatives were found to inhibit recombinant Escherichia coli peptide deformylase activity containing either zinc or cobalt. The