3-(5-Chloro-2,4-dihydroxyphenyl)-pyrazole-4-carboxamides as Inhibitors of the Hsp90 Molecular Chaperone.
✍ Scribed by Paul A. Brough; Xavier Barril; Mandy Beswick; Brian W. Dymock; Martin J. Drysdale; Lisa Wright; Kate Grant; Andrew Massey; Allan Surgenor; Paul Workman
- Publisher
- John Wiley and Sons
- Year
- 2006
- Weight
- 38 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0931-7597
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## Abstract The three‐dimensional structure of the title compound has been established by means of an X‐ray analysis. The product was formed by a thermal 1,3‐dipolar cycloaddition. According to the concerted [~π~4~__s__~ + ~π~2~__s__~]‐mechanism the formation of this stereoisomer should actually be