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HSP90 and the chaperoning of cancer

✍ Scribed by Whitesell, Luke; Lindquist, Susan L.


Book ID
109947477
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
444 KB
Volume
5
Category
Article
ISSN
1474-1776

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Hsp90 is an ATP dependent molecular chaperone involved in the folding and activation of an unknown number of substrate proteins. These substrate proteins include protein kinases and transcription factors. Consistent with this task, Hsp90 is an essential protein in all eucaryotes. The interaction of