## Abstract The past decade has seen the emergence of a new mechanistic paradigm of cancer therapeutics. Not only have mitochondria taken centre stage as key cellular organelles mediating intrinsic pathways of cell death by apoptosis, but nonapoptotic pathways have also been shown to involve mitoch
โฆ LIBER โฆ
Compartmentalized cancer drug discovery targeting mitochondrial Hsp90 chaperones
โ Scribed by Kang, B H; Altieri, D C
- Book ID
- 109971028
- Publisher
- Nature Publishing Group
- Year
- 2009
- Tongue
- English
- Weight
- 576 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0950-9232
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Conventional anticancer therapy using cytotoxic drugs lacks selectivity and is prone to toxicity and drug resistance. Anticancer therapies targeting aberrant growth factor receptor signaling are gaining interest. The erbB receptor family belongs to the type I, the receptor tyrosine kinases class, an