𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Targeted inhibition of mitochondrial Hsp90 suppresses localised and metastatic prostate cancer growth in a genetic mouse model of disease

✍ Scribed by Kang, B H; Tavecchio, M; Goel, H L; Hsieh, C-C; Garlick, D S; Raskett, C M; Lian, J B; Stein, G S; Languino, L R; Altieri, D C

Book ID
109838875
Publisher
Nature Publishing Group
Year
2011
Tongue
English
Weight
485 KB
Volume
104
Category
Article
ISSN
0007-0920

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Purine nucleoside phosphorylase and flud
Purine nucleoside phosphorylase and fludarabine phosphate gene-directed enzyme prodrug therapy suppresses primary tumour growth and pseudo-metastases in a mouse model of prostate cancer
✍ Rosetta Martiniello-Wilks; Xiao Yang Wang; Dale J. Voeks; Allison Dane; Jan M. S 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 574 KB

## Abstract Gene‐directed enzyme prodrug therapy based on the __E. coli__ purine nucleoside phosphorylase (PNP) gene produces efficient tumour cell killing. PNP converts adenosine analogs into toxic metabolites that diffuse across cell membranes to kill neighbouring untransduced cells (PNP‐GDEPT).

Inhibition of cell proliferation, invasi
Inhibition of cell proliferation, invasion, tumor growth and metastasis by an oral non-antimicrobial tetracycline analog (COL-3) in a metastatic prostate cancer model
✍ Bal L. Lokeshwar; Marie G. Selzer; Bao-Qian Zhu; Norman L. Block; Lorne M. Golub 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 460 KB

## Abstract Antibiotic forms of tetracycline exhibit antitumor activity in some tumor models. However, their low __in vivo__ efficacy and associated morbidity limit their long‐term application in cancer therapy. This report appraises the efficacy of doxycycline (DC) and non‐antimicrobial, chemicall