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Inhibitors of Acyl CoA:Cholesterol Acyltransferase

โœ Scribed by Vaccaro, Wayne; Amore, Cindy; Berger, Joel; Burrier, Robert; Clader, John; Davis, Harry; Domalski, Martin; Fevig, Tom; Salisbury, Brian; Sher, Rosy


Book ID
120630327
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
549 KB
Volume
39
Category
Article
ISSN
0022-2623

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Inhibitors of acyl-coa:cholesterol acylt
โœ Bruce D. Roth; W. Howard Roark; Joseph A. Picard; Richard L. Stanfield; Richard ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 206 KB

A series of sulfonylureas were prepared and tested for the ability to inhibit the enzyme acyl-CoA: cholesterol acyltransferase (ACAT) in vitro and lower plasma cholesterol in cholesterol-fed rats in vivo. Although compounds from this series were generally weak inhibitors of ACAT in vitro, several di