Inhibitors of acyl-coa:cholesterol acylt
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Bruce D. Roth; W. Howard Roark; Joseph A. Picard; Richard L. Stanfield; Richard
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Article
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1995
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Elsevier Science
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English
β 206 KB
A series of sulfonylureas were prepared and tested for the ability to inhibit the enzyme acyl-CoA: cholesterol acyltransferase (ACAT) in vitro and lower plasma cholesterol in cholesterol-fed rats in vivo. Although compounds from this series were generally weak inhibitors of ACAT in vitro, several di