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ChemInform Abstract: Inhibitors of Acyl-COA:Cholesterol Acyltransferase (ACAT). Part 15. Sulfonylurea Inhibitors with Excellent Hypocholesterolemic Activity in vivo.

✍ Scribed by B. D. ROTH; W. H. ROARK; J. A. PICARD; R. L. STANFIELD; R. F. BOUSLEY; M. K. ANDERSON; K. L. HAMELEHLE; R. HOMAN; B. R. KRAUSE


Book ID
112027894
Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
27
Category
Article
ISSN
0931-7597

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Inhibitors of acyl-coa:cholesterol acylt
✍ Bruce D. Roth; W. Howard Roark; Joseph A. Picard; Richard L. Stanfield; Richard πŸ“‚ Article πŸ“… 1995 πŸ› Elsevier Science 🌐 English βš– 206 KB

A series of sulfonylureas were prepared and tested for the ability to inhibit the enzyme acyl-CoA: cholesterol acyltransferase (ACAT) in vitro and lower plasma cholesterol in cholesterol-fed rats in vivo. Although compounds from this series were generally weak inhibitors of ACAT in vitro, several di