ChemInform Abstract: Inhibitors of Acyl-CoA: Cholesterol O-Acyl Transferase (ACAT) as Hypocholesterolemic Agents. Part 12. Syntheses and Biological Activity of Structurally Novel Tetrazole Amides.
β Scribed by P. M. O'BRIEN; D. R. SLISKOVIC; M. K. ANDERSON; R. F. BOUSLEY; B. R. KRAUSE; R. L. STANFIELD
- Book ID
- 112023066
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 32 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0931-7597
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The synthesis and structure-activity relationships of a series of malonester amide ACAT inhibitors are described. One of these compounds, 4s, was shown to be a potent inhibitor of both the intestinal and arterial enzymes, bioactive upon oral dosing (ex vivo bioassay) and efficacious in a clinically
The syntheses and biological activities for anilides derived from 2-phenyl-2-(dodecyl-2H-tetrazol-5-yl)acetic acid are described. Evidence is provided that one of these compounds, (+)-8b, stereoselectively inhibits ACAT in vitro and possesses superior efficacy in vivo compared to (-)-8b or the racem