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Inhibition of TPA-Induced Protein Kinase C and Transcription Activator Protein-1 Binding Activities by Theaflavin-3,3‘-digallate from Black Tea in NIH3T3 Cells

✍ Scribed by Chen, Yen-Chou; Liang, Yu-Chih; Lin-Shiau, Shoei-Yn; Ho, Chi-Tang; Lin, Jen-Kun


Book ID
127240287
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
220 KB
Volume
47
Category
Article
ISSN
0021-8561

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Crocetin, a carotenoid isolated from the seeds of Gardeniajasminoides, was found to be a potent inhibitor of tumor promotion induced by 12-0-tetradecanoy1phorbo1-13-acetate (TPA) in mouse skin. When mouse fibroblast NIH/3T3 cells were treated with TPA alone, protein kinase C (PKC) translocated from