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Interferon inhibition of DNA synthesis in Swiss 3T3 cells: Dissociation from protein kinase C activation

โœ Scribed by Huseyin Mehmet; Clive MG Morris; Joyce Taylor-Papadimitriou; Enrique Rozengurt


Book ID
115760963
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
394 KB
Volume
145
Category
Article
ISSN
0006-291X

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The effects of the anti-cancer anthracyclines doxorubicin and daunorubicin on the activity of protein kinase C (PKC) were examined in intact Swiss 3T3 cells. The 2 drugs stimulated the phosphorylation of an 80K phosphoprotein found to be identical to that generated in response to the PKC activator 1

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