Inhibition of Ribonucleic Acid Synthesis in Mouse Skin by Actinomycin D and 7,12-Dimethylbenz[α]anthracene
✍ Scribed by FLAMM, W. G.; COUNTS, W. B.; BANERJEE, M. R.
- Book ID
- 109650295
- Publisher
- Nature Publishing Group
- Year
- 1966
- Tongue
- English
- Weight
- 422 KB
- Volume
- 210
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/210541a0
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📜 SIMILAR VOLUMES
Actinomycin D (0.008 pg/gm of body weight) injected intraperitoneally every two hours, produced a prompt 50% inhibition of RNA synthesis in the jejunum of mice, and a delayed inhibition of DNA synthesis, that reached its maximum inhibition (68% of control values) 4.5 hours after the first injection
The effects of retinol and retinoic acid on unscheduled DNA synthesis (UDS) in primary Sprague-Dawley rat hepatocytes were studied in the presence and absence of known chemical and physical mutagens. Neither retinol nor retinoic acid caused a significant increase in UDS over solvent control at conce