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Codon 61 Mutations in the c-Harvey-ras Gene in Mouse Skin Tumors Induced by 7,12-Dimethylbenz[a]anthracene Plus Okadaic Acid Class Tumor Promoters

✍ Scribed by Hirota Fujiki; Masami Suganuma; Shigeru Yoshizawa; Hiroshi Kanazawa; Takashi Sugimura; Sujata Manam; Scott M. Kahn; Wei Jiang; Sadayori Hoshina; I. Bernard Weinstein

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 419 KB
Volume: 2
Category: Article
ISSN: 0899-1987
DOI: 10.1002/mc.2940020403

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Low frequency of codon 61 Ha-ras mutations and lack of keratin 13 expression in 7,12-dimethylbenz[a]-anthracene—induced hamster skin tumors

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## Abstract Alterations in the pattern of keratin expression are a common feature of skin‐tumor development. In this study, we investigated whether the loss of epidermal keratin 1 (K1) and its replacement by mucosal keratin 13 (K 13) is unique to mouse skin tumors induced by 7,12‐dimethylbenz[__a__