Inhibition of polyphosphoinositide phosphodiesterase by aminoglycoside antibiotics
β Scribed by Lucio A. A. Rooijen; Bernard W. Agranoff
- Publisher
- Springer
- Year
- 1985
- Tongue
- English
- Weight
- 279 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0364-3190
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π SIMILAR VOLUMES
formed with CEZ and SISO (C). The IR spectra were recorded as mulls in liquid paraffin (Nujol) on a Shimadzu 1R-420 spectrophotometer.
## Abstract This work describes a straightforward and sensitive method for the multiβresidue analysis of aminoglycoside antibiotics (kanamycin B, amikacin, neomycin B and paromomycin I) in bovine milk samples. The method involves the preβcapillary derivatization of antibiotics with sulfoindocyanine
Electrospray ionization mass spectrometry (ESI-MS) has been used to determine the dissociation constants (K(D)s) and binding stoichiometry for tobramycin and paromomycin with a 27-nucleotide RNA construct representing the A-site of the 16S ribosomal RNA. K(D) values determined by holding the ligand