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Inhibition of Type 4 Cyclic Nucleotide Phosphodiesterase by 8-Chloroxanthines

โœ Scribed by Jonathan R. S. Arch; Derek R. Buckle; Brendan J. Connolly; Andrew Faller; Ashley E. Fenwick; Kenneth J. Murray; Harshad K. Rami; Mark S. Smallridge; David G. Smith


Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
398 KB
Volume
329
Category
Article
ISSN
0365-6233

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Inhibition of Antigen-induced Pulmonary
โœ R.E. Howell; L.P. Jenkins; L.E. Fielding; D. Grimes ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Elsevier ๐ŸŒ English โš– 446 KB

SUMMARY: Rolipram, a phosphodiesterase type 4 (PDE4)-selective inhibitor, has been demonstrated to inhibit antigen-induced pulmonary eosinophilia in guinea pigs and monkeys, suggesting that PDE4-selective inhibitors could be useful for treating asthma. Although the rat is used extensively in preclin