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Voltage-dependent inhibition of rat skeletal muscle sodium channels by aminoglycoside antibiotics

✍ Scribed by AdrianJ. Yeiser; JamesR. Cox; SterlingN. Wright

Publisher
Springer
Year
2004
Tongue
English
Weight
288 KB
Volume
448
Category
Article
ISSN
0031-6768

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Use dependence of sodium current inhibition by tetrodotoxin in rat cardiac muscle: influence of channel state
✍ Roland Eickhorn; JΓΆrg Weirich; Daniela Hornung; Hermann Antoni πŸ“‚ Article πŸ“… 1990 πŸ› Springer 🌐 English βš– 943 KB

Tetrodoxin (TTX) is known to cause a voltageand frequency-dependent inhibition of the rapid inward sodium current (IN,) of cardiac muscle. This effect was studied by means of the loose-patch-clamp method on intact rat papillary muscle. The availability curve of the fast sodium system, determined by