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Selective inhibition by riluzole of voltage-dependent sodium channels and catecholamine secretion in adrenal chromaffin cells

✍ Scribed by Hiroki Yokoo; Seiji Shiraishi; Hideyuki Kobayashi; Toshihiko Yanagita; Ryuichi Yamamoto; A. Wada


Publisher
Springer-Verlag
Year
1998
Tongue
English
Weight
115 KB
Volume
357
Category
Article
ISSN
0028-1298

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We investigated the effects of amitriptyline, a tricyclic antidepressant, on [3H]norepinephrine ([3H]NE) secretion and ion flux in bovine adrenal chromaffin cells. Amitriptyline inhibited [3H]NE secretion induced by 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP) and 70 mM K+. The half maximal inhib