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Inhibition of Phosphatidylinositol 3-Kinase Blocks T Cell Antigen Receptor/CD3-Induced Activation of the Mitogen-Activated Kinase Erk2

✍ Scribed by Maria Von Willebrand; Thomas Jascur; Nathalie Bonnefoy-Bérard; Hiroshi Yano; Amnon Altman; Yuzuru Matsuda; Tomas Mustelin


Book ID
115131909
Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
1006 KB
Volume
235
Category
Article
ISSN
1432-1327

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## HIV induces activation of phosphatidylinositol 4-kinase and mitogen-activated protein kinase by interacting with T cell CD4 surface molecules T cell surface CD4 molecules act as co-receptors that amplify the T cell receptor (TcR)/CD3-induced signal transduction by a mechanism that requires the