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Prolongation of insulin-induced activation of mitogen-activated protein kinases ERK 1/2 and phosphatidylinositol 3-kinase by vanadyl sulfate, a protein tyrosine phosphatase inhibitor

✍ Scribed by Jean-François Théberge; Mohamad Z Mehdi; Sanjay K Pandey; Ashok K Srivastava


Book ID
116176810
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
340 KB
Volume
420
Category
Article
ISSN
0003-9861

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The observation that mitogen-activated protein (MAP) kinases ERK1 and ERK2 are constitutively activated in a number of oncogene-transformed cell lines has led to the hypothesis that prolonged activation of these enzymes is required for the transformation process. To investigate this question, we hav