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Inhibition of osteoclast proton transport by bafilomycin A1 abolishes bone resorption

✍ Scribed by Kai Sundquist; Päivi Lakkakorpi; Björn Wallmark; Kalervo Väänänen

Book ID
115763467
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
284 KB
Volume
168
Category
Article
ISSN
0006-291X

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## Abstract We confirmed the expression of cathepsin K, the most abundant and specific cysteine protease found in osteoclasts, at the mRNA level in most of our cases of breast cancer, and even at the protein level in bone metastatic lesions. Therefore, we investigated the functions of cathepsin K i