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Inhibition of experimental bone resorption and osteoclast formation and survival by 2-aminoethanesulphonic acid

โœ Scribed by Masanori Koide; Nobuo Okahashi; Rumi Tanaka; Keiko Kazuno; Ken-ichiro Shibasaki; Yoji Yamazaki; Kenji Kaneko; Nobuo Ueda; Masahiro Ohguchi; Yuichi Ishihara; Toshihide Noguchi; Tatsuji Nishihara

Book ID
113988968
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
195 KB
Volume
44
Category
Article
ISSN
0003-9969

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## Abstract We confirmed the expression of cathepsin K, the most abundant and specific cysteine protease found in osteoclasts, at the mRNA level in most of our cases of breast cancer, and even at the protein level in bone metastatic lesions. Therefore, we investigated the functions of cathepsin K i