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Inhibition of osteoclast differentiation and bone resorption by a novel lysophosphatidylcholine derivative, SCOH

✍ Scribed by Han Bok Kwak; Soo Woong Lee; Yin-Ji Li; Young-Ah Kim; So-Yeop Han; Gil-Ja Jhon; Hong-Hee Kim; Zang Hee Lee

Book ID
113487019
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
404 KB
Volume
67
Category
Article
ISSN
0006-2952

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Inhibition of osteoclast differentiation
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## Abstract We confirmed the expression of cathepsin K, the most abundant and specific cysteine protease found in osteoclasts, at the mRNA level in most of our cases of breast cancer, and even at the protein level in bone metastatic lesions. Therefore, we investigated the functions of cathepsin K i