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Inhibition of bone resorption by alendronate and risedronate does not require osteoclast apoptosis

✍ Scribed by J.M. Halasy-Nagy; G.A. Rodan; A.A. Reszka


Book ID
117807498
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
233 KB
Volume
29
Category
Article
ISSN
8756-3282

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## Abstract We confirmed the expression of cathepsin K, the most abundant and specific cysteine protease found in osteoclasts, at the mRNA level in most of our cases of breast cancer, and even at the protein level in bone metastatic lesions. Therefore, we investigated the functions of cathepsin K i