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Dexamethasone inhibits bone resorption by indirectly inducing apoptosis of the bone-resorbing osteoclasts via the action of osteoblastic cells

โœ Scribed by Shintaro Warabi; Yomei Tachibana; Masayoshi Kumegawa; Yoshiyuki Hakeda


Book ID
110259427
Publisher
Springer
Year
2001
Tongue
English
Weight
126 KB
Volume
35
Category
Article
ISSN
0920-9069

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โœ Eijiro Jimi; Ichiro Nakamura; Le T. Duong; Tetsuro Ikebe; Naoyuki Takahashi; Gid ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 519 KB

Interleukin-1 (IL-1) is one of the most potent boneresorbing factors involved in bone loss associated with inflammation. We previously reported that IL-1 prolonged the survival of multinucleated osteoclastlike cells (OCLs) formed in cocultures of murine osteoblasts/stromal cells and bone marrow cell