The active metabolite of leflunomide, A771726, inhibits both the generation of and the bone-resorbing activity of osteoclasts by acting directly on cells of the osteoclast lineage
β Scribed by Yukinao Kobayashi; Seiichi Ueyama; Yoshinori Arai; Yasushi Yoshida; Toshio Kaneda; Takuya Sato; Kitetsu Shin; Masayoshi Kumegawa; Yoshiyuki Hakeda
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 262 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0914-8779
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The present study was performed to examine the effect of the high concentration of extracellular calcium ([Ca^2+^]~e~) on osteoclastβlike cell formation and boneβresorbing activity in the presence or absence of osteoblasts. High [Ca^2+^]~e~ (3 and 5 mM) significantly stimulated osteocla
It is unknown whether the soluble factors produced from cells activated by wear particles in the fibrous tissue around failed joint prostheses really activate osteoclastic bone resorption. In this study, the activation of osteoclast-mediated bone resorption by the products from a rabbit synovial cel
It was shown previously that mouse bone marrow cells transformed by simian virus 40 (SV40) show a reversible cell density-dependent phenotypic transition between the nonmacrophage (rapidly growing) and the macrophage (stationary) states; cells in low-density cultures are in the growing phase, expres