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Inhibition of mammalian target of rapamycin: Two goals with one shot?

✍ Scribed by Christopher Soll; Pierre-Alain Clavien

Book ID
116652264
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
366 KB
Volume
54
Category
Article
ISSN
0168-8278

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## Abstract The mammalian target of rapamycin (mTOR) is a downstream effector of the phosphatidylinositol 3‐kinase (PI3K)/Akt (protein kinase B) signaling pathway, which mediates cell survival and proliferation. mTOR regulates essential signal‐transduction pathways, is involved in the coupling of g

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P anwalkar and colleagues present a very complete overview on the evolving role of mammalian target of rapamycin (mTOR) inhibitors in the treatment of both hematologic and nonhematologic malignancies. We wish to clarify selected statements made by the authors. We would like to point out that all mT