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Inhibition of the mammalian target of rapamycin impedes lymphangiogenesis

✍ Scribed by Huber, S; Bruns, C J; Schmid, G; Hermann, P C; Conrad, C; Niess, H; Huss, R; Graeb, C; Jauch, K-W; Heeschen, C; Guba, M

Book ID: 126835759
Publisher: Nature Publishing Group
Year: 2007
Tongue: English
Weight: 222 KB
Volume: 71
Category: Article
ISSN: 0085-2538
DOI: 10.1038/sj.ki.5002112

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## Abstract The mammalian target of rapamycin (mTOR) is a downstream effector of the phosphatidylinositol 3‐kinase (PI3K)/Akt (protein kinase B) signaling pathway, which mediates cell survival and proliferation. mTOR regulates essential signal‐transduction pathways, is involved in the coupling of g