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Mammalian target of rapamycin inhibition as therapy for hematologic malignancies

✍ Scribed by Corey Cutler; Joseph H. Antin

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 32 KB
Volume: 101
Category: Article
ISSN: 0008-543X
DOI: 10.1002/cncr.20495

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✦ Synopsis

P anwalkar and colleagues present a very complete overview on the evolving role of mammalian target of rapamycin (mTOR) inhibitors in the treatment of both hematologic and nonhematologic malignancies. We wish to clarify selected statements made by the authors.

We would like to point out that all mTOR inhibitors associate with an immunophilin molecule before their interaction with mTOR. Although there are numerous immunophilins, rapamycin and its analogs bind to FKBP12. It is the rapamycin-FKBP12 complex that, in turn, binds to mTOR. 2 'FKBP12' is not an alternative name for mTOR.

CCI-779, a novel mTOR inhibitor, is not Sirolimus, as the authors suggest. Sirolimus is the chemical name assigned to rapamycin (Rapamune; Wyeth, Madison, NJ). CCI-779 is the soluble esterified form of sirolimus that currently is under development.

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