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Inhibition of Interleukin-2 Messenger RNA in Mouse Lymphocytes by 2′-Deoxycoformycin and Adenosine Metabolites

✍ Scribed by MARVIN B. COHEN; ROBERT I. GLAZER

Book ID
118722572
Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
377 KB
Volume
451
Category
Article
ISSN
0890-6564

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## Abstract Cholera toxin irreversibly activates a 43‐kDa guanosine triphosphate (GTP)‐binding protein by adenosine diphosphate ribosylation, resulting in activation of adenylate cyclase and increased intracellular levels of cyclic adenosine monophosphate (cAMP). Because increases in intracellular