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In vivo inhibition of adenosine deaminase by 2'-deoxycoformycin in mouse blood and leukemia L1210 cells

โœ Scribed by Ram P. Agarwal


Book ID
115775188
Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
630 KB
Volume
29
Category
Article
ISSN
0006-2952

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Methionine-auxotrophic L1210 cells were used to study the effect of methotrexate (MTX) on methionine uptake and metabolism. MTX was shown to inhibit amino acid transport systems and cause a decrease of methionine uptake into L1210 cells. Conversely, a nonmetabolizable amino acid analogue reduced MTX