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Inhibition of methionine uptake by methotrexate in mouse leukemia L1210 cells

✍ Scribed by Kevin J. Scanlon; Arlene R. Cashmore; Mohammed Kashani-Sabet; Michele Pallai; Robert N. Dreyer; Barbara A. Moroson; Maria Saketos

Publisher
Springer
Year
1987
Tongue
English
Weight
355 KB
Volume
19
Category
Article
ISSN
0344-5704

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✦ Synopsis

Methionine-auxotrophic L1210 cells were used to study the effect of methotrexate (MTX) on methionine uptake and metabolism. MTX was shown to inhibit amino acid transport systems and cause a decrease of methionine uptake into L1210 cells. Conversely, a nonmetabolizable amino acid analogue reduced MTX uptake into L1210 cells. MTX also blocked the transfer of the beta carbon from serine into methionine. Therefore, methionine deprivation may be an additional mechanism of action for MTX in methionine-auxotrophic tumor cells.

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