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The role of methionine in methotrexate-sensitive and methotrexate-resistant mouse leukemia L1210 cells

โœ Scribed by Kevin J Scanlon; Mohammed Kashani-Sabet; Arlene R. Cashmore; Michele Pallai; Barbara A. Moroson; Maria Saketos

Publisher
Springer
Year
1987
Tongue
English
Weight
471 KB
Volume
19
Category
Article
ISSN
0344-5704

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Methionine-auxotrophic L1210 cells were used to study the effect of methotrexate (MTX) on methionine uptake and metabolism. MTX was shown to inhibit amino acid transport systems and cause a decrease of methionine uptake into L1210 cells. Conversely, a nonmetabolizable amino acid analogue reduced MTX

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## Cells res&tant to methotrexate (LI210/R7A) and possessing an increased level of dihydrofolate reductase due to gene amplification can be detected by the technique of flow cytofluorimetry using a new fluorescent derivative of methotrexate (F-MTX) based on a putrescine linker. Comparative studies o