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Inhibition of macromolecular synthesis in L1210 mouse leukemia ascites cells by hycanthone

โœ Scribed by Robert G. Wilson; Richard H. Bodner; Glenn E. Macwhorter

Book ID
115745948
Publisher
Elsevier Science
Year
1975
Weight
517 KB
Volume
378
Category
Article
ISSN
0005-2787

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Methionine-auxotrophic L1210 cells were used to study the effect of methotrexate (MTX) on methionine uptake and metabolism. MTX was shown to inhibit amino acid transport systems and cause a decrease of methionine uptake into L1210 cells. Conversely, a nonmetabolizable amino acid analogue reduced MTX