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Inhibition of RNA synthesis and interleukin-2 production in lymphocytes in vitro by benzene and its metabolites, hydroquinone and p-benzoquinone

✍ Scribed by Post, Gloria B.; Snyder, Robert; Kalf, George F.

Book ID
122422120
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
520 KB
Volume
29
Category
Article
ISSN
0378-4274

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Using radio-iron uptake into erythrocytes as a measure of hematopoiesis, it was demonstrated that p benzoquinone (BQ) and muconaldehyde (MUC) are potent inhibitors of bone marrow function in female mice. These two benzene metabolites reduced iron uptake at dosages of <5-6 mg kg-'. The combination of