𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Inhibition of HIV reverse transcriptase by 2′,3′-dideoxynucleoside triphosphates

✍ Scribed by Ming S. Chen; Scott C. Oshana

Book ID
115780006
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
226 KB
Volume
36
Category
Article
ISSN
0006-2952

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Inhibition of human immunodeficiency vir
Inhibition of human immunodeficiency virus reverse transcriptase by 2′,3′-dideoxynucleoside triphosphates: Template dependence, and combination with phosphonoformate
✍ Milbrey C. Starnes; Yung-Chi Cheng 📂 Article 📅 1989 🏛 Springer 🌐 English ⚖ 840 KB

The 2',3'-dideoxynucleoside triphosphates (ddNTPs) are potent substrate analog inhibitors of human immunodeficiency virus (HIV) reverse transcriptase and have clinical utility in the treatment of acquired immunodeticiency syndrome. Several issues regarding the interaction of these compounds with HIV

3′-Substituted and 2′,3′-Unsaturated 7-D
3′-Substituted and 2′,3′-Unsaturated 7-Deazaguanine 2′,3′-Dideoxynucleosides: Syntheses and Inhibition of HIV-1 Reverse Transcriptase
✍ Frank Seela; Heinz-Peter Muth 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 German ⚖ 659 KB

The syntheses of 2',3'-dideoxy-2',3'-didehydro-~-o-ribofuranoside 1 and 2',3'-dideoxy-3'-fluoro-p-~-ribofuranoside 5 of 7-deazaguanine as well as 7-deaza-2'-deoxyxyloguanosine (3) are described. The corresponding 2,4-diamino compounds 2 and 4 were also prepared. Thus, silylation of 2-amino-4-chloro-