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Inhibition of HIV-1 reverse transcriptase by 5′-triphosphates of 5-substituted uridine analogs

✍ Scribed by Pei-Zhen Tao; Nils Gunnar Johansson; Göran Stening; Bo Öberg; Roelf Datema


Book ID
118392144
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
478 KB
Volume
12
Category
Article
ISSN
0166-3542

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Inhibition of uridine-cytidine kinase by
✍ Lee, Thomas T. ;Momparler, Richard L. 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 English ⚖ 299 KB

## Abstract 5‐Azacytidine 5′‐triphosphate (5‐aza‐CTP) inhibited the phosphorylation of uridine, cytidine, and 5‐azacytidine (5‐aza‐C) in a reaction catalyzed by uridine‐cytidine kinase. The inhibition appeared to be competitive with respect to the adenosine 5′‐triphosphate and noncompetitive with r