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Inhibition of human immunodeficiency virus 1 reverse transcriptase by 3′-azidothymidine triphosphate

✍ Scribed by Olaf HEIDENREICH; Mogens KRUHØFFER; Frank GROSSE; Fritz ECKSTEIN

Book ID
115128129
Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
501 KB
Volume
192
Category
Article
ISSN
1432-1327

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Inhibition of human immunodeficiency vir
Inhibition of human immunodeficiency virus reverse transcriptase by 2′,3′-dideoxynucleoside triphosphates: Template dependence, and combination with phosphonoformate
✍ Milbrey C. Starnes; Yung-Chi Cheng 📂 Article 📅 1989 🏛 Springer 🌐 English ⚖ 840 KB

The 2',3'-dideoxynucleoside triphosphates (ddNTPs) are potent substrate analog inhibitors of human immunodeficiency virus (HIV) reverse transcriptase and have clinical utility in the treatment of acquired immunodeticiency syndrome. Several issues regarding the interaction of these compounds with HIV