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Inhibition of the reverse transcriptase from HIV by 3′-azido-3′-deoxythymidine triphosphate and its threo analogue

✍ Scribed by Lotta Vrang; Hervé Bazin; Gerald Remaud; Jyoti Chattopadhyaya; Bo Öberg


Book ID
118391829
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
540 KB
Volume
7
Category
Article
ISSN
0166-3542

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Inhibition of hepatitis B virus DNA poly
✍ E. Nordenfelt; Bengt Löfgren; Jyoti Chattopadhyaya; Bo Öberg 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 301 KB 👁 2 views

An inhibitory effect of 3'-azido-3'-deoxythymidine triphosphate on hepatitis B virus DNA polymerase was found. No effect was seen by its threo analog. The effect was detected at and above a concentration of 0.05 microM. The inhibition of DNA polymerase activity was the same in ten different strains