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Inhibition of hepatitis B virus DNA polymerase by 3′-azido-3′-deoxythymidine triphosphate but not by its threo analog

✍ Scribed by E. Nordenfelt; Bengt Löfgren; Jyoti Chattopadhyaya; Bo Öberg

Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
301 KB
Volume
22
Category
Article
ISSN
0146-6615

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✦ Synopsis

An inhibitory effect of 3'-azido-3'-deoxythymidine triphosphate on hepatitis B virus DNA polymerase was found. No effect was seen by its threo analog. The effect was detected at and above a concentration of 0.05 microM. The inhibition of DNA polymerase activity was the same in ten different strains of HBV. The mechanism was shown to be competitive, with an inhibition constant (Ki) of approximately 0.04 microM, and the Km value for dTTP was 0.1 microM.

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