## Abstract It has been admitted that urokinaseβtype plasminogen activator receptor (uβPAR) is overexpressed in many human malignant tumors including oral squamous cell carcinoma (OSCC) and plays an important role in a variety of cancer key cellular events as a versatile signaling orchestrator. In
β¦ LIBER β¦
Inhibition of FAK signaling activated by urokinase receptor induces dormancy in human carcinoma cells in vivo
β Scribed by Aguirre Ghiso, Julio A
- Book ID
- 110066543
- Publisher
- Nature Publishing Group
- Year
- 2002
- Tongue
- English
- Weight
- 527 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0950-9232
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Urokinase (u-PA) and the urokinase receptor (u-PAR), are thought to play a critical role in the invasive and metastatic properties of cancer cells. The HT29 human colon-carcinoma cell line was selected to evaluate these aspects. HT29 cells express u-PA receptors (100,000 sitedcell, K, = I .5 nM), bu