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Downregulation of urokinase-type plasminogen activator receptor (uPAR) induces caspase-mediated cell death in human glioblastoma cells

✍ Scribed by Niranjan Yanamandra; Santhi D. Konduri; Sanjeeva Mohanam; Dzung H. Dinh; William C. Olivero; Meena Gujrati; Garth L. Nicolson; Mandri Obeyeseke; Jasti S. Rao


Book ID
110307627
Publisher
Springer
Year
2000
Tongue
English
Weight
123 KB
Volume
18
Category
Article
ISSN
0262-0898

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Urokinase type plasminogen activator rec
✍ Marisa A. Gallicchio; Christoph Kaun; Johann Wojta; Bernd Binder; Leon A. Bach πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 143 KB

## Abstract Urokinase‐type plasminogen activator (uPA) binds to its receptor, uPAR, on the surface of cancer cells, leading to the formation of plasmin. Rhabdomyosarcoma (RMS) cell lines secrete high levels of insulin‐like growth factor II (IGF‐II), suggesting autocrine IGFs play a major role in th