Activation of cAMP–PKA signaling in vivo inhibits smooth muscle cell proliferation induced by vascular injury
✍ Scribed by Indolfi, Ciro; Vittorio Avvedimento, Enrico; Lorenzo, Emilio Di; Esposito, Giovanni; Rapacciuolo, Antonio; Giuliano, Paola; Grieco, Domenico; Cavuto, Luigi; Stingone, Angela M.; Ciullo, Ilaria
- Book ID
- 109929470
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 549 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1078-8956
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Cyclic AMP (cAMP) is a pleiotropic second messenger that regulates numerous cellular processes. In vascular smooth muscle cells (VSMCs), these include cell proliferation, migration, and contractility. Here we show that cAMP‐elevating agents induce dramatic morphological changes in VSMCs
Lysyl oxidase (LO) is a key participant in the accumulation of insoluble fibers of elastin and collagen by virtue of its role in the initiation of the covalent cross-linkages between and within individual molecules comprising these fibers. In view of the essential role played by LO in the accumulati