Inhibition of Epidermal Growth Factor Receptor Signaling Decreases p63 Expression in Head and Neck Squamous Carcinoma Cells
โ Scribed by Keith E. Matheny; Christopher E. Barbieri; Joseph C. Sniezek; Carlos L. Arteaga; Jennifer A. Pietenpol
- Book ID
- 110084363
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 387 KB
- Volume
- 113
- Category
- Article
- ISSN
- 0023-852X
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## Abstract ## Background Cumulative evidence implicates the epidermal growth factor receptor (EGFR) as an important therapeutic target in head and neck squamous cell carcinoma (HNSCC). The basis for the lack of correlation between EGFR expression in the HNSCC tumor and clinical responses to EGFR
## Abstract The degree of gene amplification for epidermal growth factor receptor (EGFR) and its expression levels were examined in 4 cases of tumor lesions and their cell lines of human squamous cell carcinoma (SCC) of the oral cavity. The amplification was detected in 1 case (ZA), but not signifi