Expression and mutation analysis of epidermal growth factor receptor in head and neck squamous cell carcinoma
โ Scribed by Mahmoud A.L. Sheikh Ali; Mehmet Gunduz; Hitoshi Nagatsuka; Esra Gunduz; Beyhan Cengiz; Kunihiro Fukushima; Levent Bekir Beder; Kadir Demircan; Masae Fujii; Noboru Yamanaka; Kenji Shimizu; Reidar Grenman; Noriyuki Nagai
- Book ID
- 108584243
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 301 KB
- Volume
- 99
- Category
- Article
- ISSN
- 1347-9032
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## Abstract ## Background Cumulative evidence implicates the epidermal growth factor receptor (EGFR) as an important therapeutic target in head and neck squamous cell carcinoma (HNSCC). The basis for the lack of correlation between EGFR expression in the HNSCC tumor and clinical responses to EGFR
## Abstract The degree of gene amplification for epidermal growth factor receptor (EGFR) and its expression levels were examined in 4 cases of tumor lesions and their cell lines of human squamous cell carcinoma (SCC) of the oral cavity. The amplification was detected in 1 case (ZA), but not signifi