## Abstract High expression of the epidermal growth factor receptor (EGFR) has been implicated in the development of squamousβcell carcinomas of head and neck (SCCHN). ZD1839 (βIressaβ) is an orally active, selective EGFRβTKI (EGFRβtyrosine kinase inhibitor) that blocks signal transduction pathways
The role of epidermal growth factor receptor in head and neck squamous cell carcinoma
β Scribed by Rebecca G. Pomerantz; Jennifer Rubin Grandis
- Book ID
- 107546252
- Publisher
- Current Science Inc.
- Year
- 2003
- Tongue
- English
- Weight
- 537 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1523-3790
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## Abstract ## Background Cumulative evidence implicates the epidermal growth factor receptor (EGFR) as an important therapeutic target in head and neck squamous cell carcinoma (HNSCC). The basis for the lack of correlation between EGFR expression in the HNSCC tumor and clinical responses to EGFR
## Abstract The degree of gene amplification for epidermal growth factor receptor (EGFR) and its expression levels were examined in 4 cases of tumor lesions and their cell lines of human squamous cell carcinoma (SCC) of the oral cavity. The amplification was detected in 1 case (ZA), but not signifi
Epidermal growth factor (EGF) stimulates the growth of several types of epithelial tissues and possesses a strong mitogenic activity that is mediated through its cell surface receptor (EGFR). The aim of this study was to characterize EGFR and measure its levels in head and neck tumors biopsies (70 p