## Abstract ## Background Cumulative evidence implicates the epidermal growth factor receptor (EGFR) as an important therapeutic target in head and neck squamous cell carcinoma (HNSCC). The basis for the lack of correlation between EGFR expression in the HNSCC tumor and clinical responses to EGFR
Epidermal growth factor receptor-targeted therapy potentiates lovastatin-induced apoptosis in head and neck squamous cell carcinoma cells
โ Scribed by AngelaJ. Mantha; KathrynE. McFee; Nima Niknejad; Glenwood Goss; IanA. Lorimer; Jim Dimitroulakos
- Publisher
- Springer-Verlag
- Year
- 2003
- Tongue
- English
- Weight
- 611 KB
- Volume
- 129
- Category
- Article
- ISSN
- 1432-1335
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Epidermal growth factor (EGF) stimulates the growth of several types of epithelial tissues and possesses a strong mitogenic activity that is mediated through its cell surface receptor (EGFR). The aim of this study was to characterize EGFR and measure its levels in head and neck tumors biopsies (70 p
## Abstract Head and neck cancer is a challenging disease that is expected to account for greater than 500,000 new cases worldwide in 2008. Toxicity has impeded advances in chemotherapy and radiation for head and neck cancer, and the prognosis for patients with recurrent and/or metastatic disease r
## Abstract The degree of gene amplification for epidermal growth factor receptor (EGFR) and its expression levels were examined in 4 cases of tumor lesions and their cell lines of human squamous cell carcinoma (SCC) of the oral cavity. The amplification was detected in 1 case (ZA), but not signifi
## Abstract Noninvasive imaging of the epidermal growth factor receptor (EGFR) in headโandโneck squamous cell carcinoma could be of value to select patients for EGFRโtargeted therapy. We assessed dose optimization of ^111^IndiumโDTPAโcetuximab (^111^Inโcetuximab) for EGFR imaging in a headโandโneck