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Inhibition of connexin43 gap junction channels by the endocrine disruptor ioxynil

✍ Scribed by Edward Leithe; Ane Kjenseth; Jarle Bruun; Solveig Sirnes; Edgar Rivedal

Book ID
113924740
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
932 KB
Volume
247
Category
Article
ISSN
0041-008X

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Inhibition of connexin43 gap junctional
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✍ Randall J. Ruch; James E. Trosko; Burra V. Madhukar πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 243 KB

## Abstract The phorbol ester, 12‐__O__‐tetradecanoylphorbol‐13‐acetate (TPA), is a potent inhibitor of gap junctional intercellular communication (GJIC). This inhibition requires activation of protein kinase C (PKC), but the events downstream of this kinase are not known. Since PKC can activate ex