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Gap26, a connexin mimetic peptide, inhibits currents carried by connexin43 hemichannels and gap junction channels

✍ Scribed by T. Desplantez; V. Verma; L. Leybaert; W.H. Evans; R. Weingart

Book ID: 119346973
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 547 KB
Volume: 65
Category: Article
ISSN: 1043-6618
DOI: 10.1016/j.phrs.2012.02.002

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The tumor-suppressive property of the connexin gap-junction proteins was postulated from the fact that their function of cell coupling is impaired in most cancer cells. However, in conflict with this notion, certain cancer cells are able to communicate through gap junctions despite their malignancy.