Cardiac connexin43 gap junction channels participate in the establishment of membrane potential and cell growth
β Scribed by Asif Sewani; Carolina Vasquez; Edward Berbari; Alonso P. Moreno
- Book ID
- 119546286
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 164 KB
- Volume
- 41
- Category
- Article
- ISSN
- 1558-3597
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## Abstract Numerous studies have demonstrated a correlation between dysregulation/loss of connexin expression or gap junction intercellular communication (GJIC) function and decreased growth control both in human tumors and tumor cell lines. Likewise, restoration of constitutive connexin expressio
## Abstract Many studies have correlated reductions in gap junctional intercellular communication (a) with altered cellular growth, tumor promotion, and neoplastic transformation. To test directly whether reduced GJIC affects cellular growth, GJIC was inhibited in murine BALB/c 3T3 fibroblasts by t